Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients.
Identifieur interne : 000093 ( Main/Exploration ); précédent : 000092; suivant : 000094Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients.
Auteurs : Myriam Remmelink [Belgique] ; Ricardo De Mendonça [Belgique] ; Nicky D'Haene [Belgique] ; Sarah De Clercq [Belgique] ; Camille Verocq [Belgique] ; Laetitia Lebrun [Belgique] ; Philomène Lavis [Belgique] ; Marie-Lucie Racu [Belgique] ; Anne-Laure Trépant [Belgique] ; Calliope Maris [Belgique] ; Sandrine Rorive [Belgique] ; Jean-Christophe Goffard [Belgique] ; Olivier De Witte [Belgique] ; Lorenzo Peluso [Belgique] ; Jean-Louis Vincent [Belgique] ; Christine Decaestecker [Belgique] ; Fabio Silvio Taccone [Belgique] ; Isabelle Salmon [Belgique]Source :
- Critical care (London, England) [ 1466-609X ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Autopsie (MeSH), Betacoronavirus (isolement et purification), Coeur (virologie), Côlon (virologie), Encéphale (virologie), Femelle (MeSH), Foie (virologie), Humains (MeSH), Infections à coronavirus (thérapie), Infections à coronavirus (virologie), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (thérapie), Pneumopathie virale (virologie), Poumon (virologie), RT-PCR (MeSH), Rate (virologie), Rein (virologie), Sujet âgé (MeSH).
- MESH :
- isolement et purification : Betacoronavirus.
- thérapie : Infections à coronavirus, Pneumopathie virale.
- virologie : Coeur, Côlon, Encéphale, Foie, Infections à coronavirus, Pneumopathie virale, Poumon, Rate, Rein.
- Adulte d'âge moyen, Autopsie, Femelle, Humains, Mâle, Pandémies, RT-PCR, Sujet âgé.
English descriptors
- KwdEn :
- Aged (MeSH), Autopsy (MeSH), Betacoronavirus (isolation & purification), Brain (virology), Colon (virology), Coronavirus Infections (therapy), Coronavirus Infections (virology), Female (MeSH), Heart (virology), Humans (MeSH), Kidney (virology), Liver (virology), Lung (virology), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (therapy), Pneumonia, Viral (virology), Reverse Transcriptase Polymerase Chain Reaction (MeSH), Spleen (virology).
- MESH :
- isolation & purification : Betacoronavirus.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- virology : Brain, Colon, Coronavirus Infections, Heart, Kidney, Liver, Lung, Pneumonia, Viral, Spleen.
- Aged, Autopsy, Female, Humans, Male, Middle Aged, Pandemics, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
BACKGROUND
Post-mortem studies can provide important information for understanding new diseases and small autopsy case series have already reported different findings in COVID-19 patients.
METHODS
We evaluated whether some specific post-mortem features are observed in these patients and if these changes are related to the presence of the virus in different organs. Complete macroscopic and microscopic autopsies were performed on different organs in 17 COVID-19 non-survivors. Presence of SARS-CoV-2 was evaluated with immunohistochemistry (IHC) in lung samples and with real-time reverse-transcription polymerase chain reaction (RT-PCR) test in the lung and other organs.
RESULTS
Pulmonary findings revealed early-stage diffuse alveolar damage (DAD) in 15 out of 17 patients and microthrombi in small lung arteries in 11 patients. Late-stage DAD, atypical pneumocytes, and/or acute pneumonia were also observed. Four lung infarcts, two acute myocardial infarctions, and one ischemic enteritis were observed. There was no evidence of myocarditis, hepatitis, or encephalitis. Kidney evaluation revealed the presence of hemosiderin in tubules or pigmented casts in most patients. Spongiosis and vascular congestion were the most frequently encountered brain lesions. No specific SARS-CoV-2 lesions were observed in any organ. IHC revealed positive cells with a heterogeneous distribution in the lungs of 11 of the 17 (65%) patients; RT-PCR yielded a wide distribution of SARS-CoV-2 in different tissues, with 8 patients showing viral presence in all tested organs (i.e., lung, heart, spleen, liver, colon, kidney, and brain).
CONCLUSIONS
In conclusion, autopsies revealed a great heterogeneity of COVID-19-associated organ injury and the remarkable absence of any specific viral lesions, even when RT-PCR identified the presence of the virus in many organs.
DOI: 10.1186/s13054-020-03218-5
PubMed: 32787909
PubMed Central: PMC7422463
Affiliations:
Links toward previous steps (curation, corpus...)
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Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Verocq, Camille" sort="Verocq, Camille" uniqKey="Verocq C" first="Camille" last="Verocq">Camille Verocq</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Lebrun, Laetitia" sort="Lebrun, Laetitia" uniqKey="Lebrun L" first="Laetitia" last="Lebrun">Laetitia Lebrun</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Lavis, Philomene" sort="Lavis, Philomene" uniqKey="Lavis P" first="Philomène" last="Lavis">Philomène Lavis</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Racu, Marie Lucie" sort="Racu, Marie Lucie" uniqKey="Racu M" first="Marie-Lucie" last="Racu">Marie-Lucie Racu</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Trepant, Anne Laure" sort="Trepant, Anne Laure" uniqKey="Trepant A" first="Anne-Laure" last="Trépant">Anne-Laure Trépant</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre Universitaire inter Régional d'expertise en Anatomie Pathologique Hospitalière (CurePath, CHIREC, CHU Tivoli, ULB), Rue de Borfilet 12A, 6040, Jumet, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Centre Universitaire inter Régional d'expertise en Anatomie Pathologique Hospitalière (CurePath, CHIREC, CHU Tivoli, ULB), Rue de Borfilet 12A, 6040, Jumet</wicri:regionArea><wicri:noRegion>Jumet</wicri:noRegion></affiliation></author><author><name sortKey="Maris, Calliope" sort="Maris, Calliope" uniqKey="Maris C" first="Calliope" last="Maris">Calliope Maris</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Rorive, Sandrine" sort="Rorive, Sandrine" uniqKey="Rorive S" first="Sandrine" last="Rorive">Sandrine Rorive</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre Universitaire inter Régional d'expertise en Anatomie Pathologique Hospitalière (CurePath, CHIREC, CHU Tivoli, ULB), Rue de Borfilet 12A, 6040, Jumet, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Centre Universitaire inter Régional d'expertise en Anatomie Pathologique Hospitalière (CurePath, CHIREC, CHU Tivoli, ULB), Rue de Borfilet 12A, 6040, Jumet</wicri:regionArea><wicri:noRegion>Jumet</wicri:noRegion></affiliation></author><author><name sortKey="Goffard, Jean Christophe" sort="Goffard, Jean Christophe" uniqKey="Goffard J" first="Jean-Christophe" last="Goffard">Jean-Christophe Goffard</name><affiliation wicri:level="4"><nlm:affiliation>Immunodeficiency Treatment Unit, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Immunodeficiency Treatment Unit, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="De Witte, Olivier" sort="De Witte, Olivier" uniqKey="De Witte O" first="Olivier" last="De Witte">Olivier De Witte</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurosurgery, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Neurosurgery, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Peluso, Lorenzo" sort="Peluso, Lorenzo" uniqKey="Peluso L" first="Lorenzo" last="Peluso">Lorenzo Peluso</name><affiliation wicri:level="4"><nlm:affiliation>Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Vincent, Jean Louis" sort="Vincent, Jean Louis" uniqKey="Vincent J" first="Jean-Louis" last="Vincent">Jean-Louis Vincent</name><affiliation wicri:level="4"><nlm:affiliation>Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Decaestecker, Christine" sort="Decaestecker, Christine" uniqKey="Decaestecker C" first="Christine" last="Decaestecker">Christine Decaestecker</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Image Synthesis and Analysis (LISA), Université Libre de Bruxelles (ULB), CPI 165/57, Avenue Franklin Roosevelt 50, 1050, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Image Synthesis and Analysis (LISA), Université Libre de Bruxelles (ULB), CPI 165/57, Avenue Franklin Roosevelt 50, 1050, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation><affiliation wicri:level="4"><nlm:affiliation>DIAPath, Center for Microscopy and Molecular Imaging, Université Libre de Bruxelles (ULB), CPI 305/1, Rue Adrienne Bolland, 8, 6041, Gosselies, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>DIAPath, Center for Microscopy and Molecular Imaging, Université Libre de Bruxelles (ULB), CPI 305/1, Rue Adrienne Bolland, 8, 6041, Gosselies</wicri:regionArea><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Taccone, Fabio Silvio" sort="Taccone, Fabio Silvio" uniqKey="Taccone F" first="Fabio Silvio" last="Taccone">Fabio Silvio Taccone</name><affiliation wicri:level="4"><nlm:affiliation>Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Salmon, Isabelle" sort="Salmon, Isabelle" uniqKey="Salmon I" first="Isabelle" last="Salmon">Isabelle Salmon</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium. Isabelle.Salmon@erasme.ulb.ac.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre Universitaire inter Régional d'expertise en Anatomie Pathologique Hospitalière (CurePath, CHIREC, CHU Tivoli, ULB), Rue de Borfilet 12A, 6040, Jumet, Belgium. Isabelle.Salmon@erasme.ulb.ac.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Centre Universitaire inter Régional d'expertise en Anatomie Pathologique Hospitalière (CurePath, CHIREC, CHU Tivoli, ULB), Rue de Borfilet 12A, 6040, Jumet</wicri:regionArea><wicri:noRegion>Jumet</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>DIAPath, Center for Microscopy and Molecular Imaging, Université Libre de Bruxelles (ULB), CPI 305/1, Rue Adrienne Bolland, 8, 6041, Gosselies, Belgium. Isabelle.Salmon@erasme.ulb.ac.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>DIAPath, Center for Microscopy and Molecular Imaging, Université Libre de Bruxelles (ULB), CPI 305/1, Rue Adrienne Bolland, 8, 6041, Gosselies</wicri:regionArea><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32787909</idno><idno type="pmid">32787909</idno><idno type="doi">10.1186/s13054-020-03218-5</idno><idno type="pmc">PMC7422463</idno><idno type="wicri:Area/Main/Corpus">000695</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000695</idno><idno type="wicri:Area/Main/Curation">000695</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000695</idno><idno type="wicri:Area/Main/Exploration">000695</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients.</title><author><name sortKey="Remmelink, Myriam" sort="Remmelink, Myriam" uniqKey="Remmelink M" first="Myriam" last="Remmelink">Myriam Remmelink</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="De Mendonca, Ricardo" sort="De Mendonca, Ricardo" uniqKey="De Mendonca R" first="Ricardo" last="De Mendonça">Ricardo De Mendonça</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="D Haene, Nicky" sort="D Haene, Nicky" uniqKey="D Haene N" first="Nicky" last="D'Haene">Nicky D'Haene</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="De Clercq, Sarah" sort="De Clercq, Sarah" uniqKey="De Clercq S" first="Sarah" last="De Clercq">Sarah De Clercq</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Verocq, Camille" sort="Verocq, Camille" uniqKey="Verocq C" first="Camille" last="Verocq">Camille Verocq</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Lebrun, Laetitia" sort="Lebrun, Laetitia" uniqKey="Lebrun L" first="Laetitia" last="Lebrun">Laetitia Lebrun</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Lavis, Philomene" sort="Lavis, Philomene" uniqKey="Lavis P" first="Philomène" last="Lavis">Philomène Lavis</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Racu, Marie Lucie" sort="Racu, Marie Lucie" uniqKey="Racu M" first="Marie-Lucie" last="Racu">Marie-Lucie Racu</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Trepant, Anne Laure" sort="Trepant, Anne Laure" uniqKey="Trepant A" first="Anne-Laure" last="Trépant">Anne-Laure Trépant</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre Universitaire inter Régional d'expertise en Anatomie Pathologique Hospitalière (CurePath, CHIREC, CHU Tivoli, ULB), Rue de Borfilet 12A, 6040, Jumet, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Centre Universitaire inter Régional d'expertise en Anatomie Pathologique Hospitalière (CurePath, CHIREC, CHU Tivoli, ULB), Rue de Borfilet 12A, 6040, Jumet</wicri:regionArea><wicri:noRegion>Jumet</wicri:noRegion></affiliation></author><author><name sortKey="Maris, Calliope" sort="Maris, Calliope" uniqKey="Maris C" first="Calliope" last="Maris">Calliope Maris</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Rorive, Sandrine" sort="Rorive, Sandrine" uniqKey="Rorive S" first="Sandrine" last="Rorive">Sandrine Rorive</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre Universitaire inter Régional d'expertise en Anatomie Pathologique Hospitalière (CurePath, CHIREC, CHU Tivoli, ULB), Rue de Borfilet 12A, 6040, Jumet, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Centre Universitaire inter Régional d'expertise en Anatomie Pathologique Hospitalière (CurePath, CHIREC, CHU Tivoli, ULB), Rue de Borfilet 12A, 6040, Jumet</wicri:regionArea><wicri:noRegion>Jumet</wicri:noRegion></affiliation></author><author><name sortKey="Goffard, Jean Christophe" sort="Goffard, Jean Christophe" uniqKey="Goffard J" first="Jean-Christophe" last="Goffard">Jean-Christophe Goffard</name><affiliation wicri:level="4"><nlm:affiliation>Immunodeficiency Treatment Unit, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Immunodeficiency Treatment Unit, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="De Witte, Olivier" sort="De Witte, Olivier" uniqKey="De Witte O" first="Olivier" last="De Witte">Olivier De Witte</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurosurgery, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Neurosurgery, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Peluso, Lorenzo" sort="Peluso, Lorenzo" uniqKey="Peluso L" first="Lorenzo" last="Peluso">Lorenzo Peluso</name><affiliation wicri:level="4"><nlm:affiliation>Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Vincent, Jean Louis" sort="Vincent, Jean Louis" uniqKey="Vincent J" first="Jean-Louis" last="Vincent">Jean-Louis Vincent</name><affiliation wicri:level="4"><nlm:affiliation>Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Decaestecker, Christine" sort="Decaestecker, Christine" uniqKey="Decaestecker C" first="Christine" last="Decaestecker">Christine Decaestecker</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Image Synthesis and Analysis (LISA), Université Libre de Bruxelles (ULB), CPI 165/57, Avenue Franklin Roosevelt 50, 1050, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Image Synthesis and Analysis (LISA), Université Libre de Bruxelles (ULB), CPI 165/57, Avenue Franklin Roosevelt 50, 1050, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation><affiliation wicri:level="4"><nlm:affiliation>DIAPath, Center for Microscopy and Molecular Imaging, Université Libre de Bruxelles (ULB), CPI 305/1, Rue Adrienne Bolland, 8, 6041, Gosselies, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>DIAPath, Center for Microscopy and Molecular Imaging, Université Libre de Bruxelles (ULB), CPI 305/1, Rue Adrienne Bolland, 8, 6041, Gosselies</wicri:regionArea><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Taccone, Fabio Silvio" sort="Taccone, Fabio Silvio" uniqKey="Taccone F" first="Fabio Silvio" last="Taccone">Fabio Silvio Taccone</name><affiliation wicri:level="4"><nlm:affiliation>Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Salmon, Isabelle" sort="Salmon, Isabelle" uniqKey="Salmon I" first="Isabelle" last="Salmon">Isabelle Salmon</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium. Isabelle.Salmon@erasme.ulb.ac.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre Universitaire inter Régional d'expertise en Anatomie Pathologique Hospitalière (CurePath, CHIREC, CHU Tivoli, ULB), Rue de Borfilet 12A, 6040, Jumet, Belgium. Isabelle.Salmon@erasme.ulb.ac.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Centre Universitaire inter Régional d'expertise en Anatomie Pathologique Hospitalière (CurePath, CHIREC, CHU Tivoli, ULB), Rue de Borfilet 12A, 6040, Jumet</wicri:regionArea><wicri:noRegion>Jumet</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>DIAPath, Center for Microscopy and Molecular Imaging, Université Libre de Bruxelles (ULB), CPI 305/1, Rue Adrienne Bolland, 8, 6041, Gosselies, Belgium. Isabelle.Salmon@erasme.ulb.ac.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>DIAPath, Center for Microscopy and Molecular Imaging, Université Libre de Bruxelles (ULB), CPI 305/1, Rue Adrienne Bolland, 8, 6041, Gosselies</wicri:regionArea><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author></analytic><series><title level="j">Critical care (London, England)</title><idno type="eISSN">1466-609X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Autopsy (MeSH)</term><term>Betacoronavirus (isolation & purification)</term><term>Brain (virology)</term><term>Colon (virology)</term><term>Coronavirus Infections (therapy)</term><term>Coronavirus Infections (virology)</term><term>Female (MeSH)</term><term>Heart (virology)</term><term>Humans (MeSH)</term><term>Kidney (virology)</term><term>Liver (virology)</term><term>Lung (virology)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (therapy)</term><term>Pneumonia, Viral (virology)</term><term>Reverse Transcriptase Polymerase Chain Reaction (MeSH)</term><term>Spleen (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Autopsie (MeSH)</term><term>Betacoronavirus (isolement et purification)</term><term>Coeur (virologie)</term><term>Côlon (virologie)</term><term>Encéphale (virologie)</term><term>Femelle (MeSH)</term><term>Foie (virologie)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (thérapie)</term><term>Infections à coronavirus (virologie)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (thérapie)</term><term>Pneumopathie virale (virologie)</term><term>Poumon (virologie)</term><term>RT-PCR (MeSH)</term><term>Rate (virologie)</term><term>Rein (virologie)</term><term>Sujet âgé (MeSH)</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Coeur</term><term>Côlon</term><term>Encéphale</term><term>Foie</term><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Poumon</term><term>Rate</term><term>Rein</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Brain</term><term>Colon</term><term>Coronavirus Infections</term><term>Heart</term><term>Kidney</term><term>Liver</term><term>Lung</term><term>Pneumonia, Viral</term><term>Spleen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Autopsy</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Autopsie</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pandémies</term><term>RT-PCR</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Post-mortem studies can provide important information for understanding new diseases and small autopsy case series have already reported different findings in COVID-19 patients.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We evaluated whether some specific post-mortem features are observed in these patients and if these changes are related to the presence of the virus in different organs. Complete macroscopic and microscopic autopsies were performed on different organs in 17 COVID-19 non-survivors. Presence of SARS-CoV-2 was evaluated with immunohistochemistry (IHC) in lung samples and with real-time reverse-transcription polymerase chain reaction (RT-PCR) test in the lung and other organs.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Pulmonary findings revealed early-stage diffuse alveolar damage (DAD) in 15 out of 17 patients and microthrombi in small lung arteries in 11 patients. Late-stage DAD, atypical pneumocytes, and/or acute pneumonia were also observed. Four lung infarcts, two acute myocardial infarctions, and one ischemic enteritis were observed. There was no evidence of myocarditis, hepatitis, or encephalitis. Kidney evaluation revealed the presence of hemosiderin in tubules or pigmented casts in most patients. Spongiosis and vascular congestion were the most frequently encountered brain lesions. No specific SARS-CoV-2 lesions were observed in any organ. IHC revealed positive cells with a heterogeneous distribution in the lungs of 11 of the 17 (65%) patients; RT-PCR yielded a wide distribution of SARS-CoV-2 in different tissues, with 8 patients showing viral presence in all tested organs (i.e., lung, heart, spleen, liver, colon, kidney, and brain).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>In conclusion, autopsies revealed a great heterogeneity of COVID-19-associated organ injury and the remarkable absence of any specific viral lesions, even when RT-PCR identified the presence of the virus in many organs.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32787909</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>18</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>01</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1466-609X</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>08</Month><Day>12</Day></PubDate></JournalIssue><Title>Critical care (London, England)</Title><ISOAbbreviation>Crit Care</ISOAbbreviation></Journal><ArticleTitle>Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients.</ArticleTitle><Pagination><MedlinePgn>495</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s13054-020-03218-5</ELocationID><Abstract><AbstractText Label="BACKGROUND">Post-mortem studies can provide important information for understanding new diseases and small autopsy case series have already reported different findings in COVID-19 patients.</AbstractText><AbstractText Label="METHODS">We evaluated whether some specific post-mortem features are observed in these patients and if these changes are related to the presence of the virus in different organs. Complete macroscopic and microscopic autopsies were performed on different organs in 17 COVID-19 non-survivors. Presence of SARS-CoV-2 was evaluated with immunohistochemistry (IHC) in lung samples and with real-time reverse-transcription polymerase chain reaction (RT-PCR) test in the lung and other organs.</AbstractText><AbstractText Label="RESULTS">Pulmonary findings revealed early-stage diffuse alveolar damage (DAD) in 15 out of 17 patients and microthrombi in small lung arteries in 11 patients. Late-stage DAD, atypical pneumocytes, and/or acute pneumonia were also observed. Four lung infarcts, two acute myocardial infarctions, and one ischemic enteritis were observed. There was no evidence of myocarditis, hepatitis, or encephalitis. Kidney evaluation revealed the presence of hemosiderin in tubules or pigmented casts in most patients. Spongiosis and vascular congestion were the most frequently encountered brain lesions. No specific SARS-CoV-2 lesions were observed in any organ. IHC revealed positive cells with a heterogeneous distribution in the lungs of 11 of the 17 (65%) patients; RT-PCR yielded a wide distribution of SARS-CoV-2 in different tissues, with 8 patients showing viral presence in all tested organs (i.e., lung, heart, spleen, liver, colon, kidney, and brain).</AbstractText><AbstractText Label="CONCLUSIONS">In conclusion, autopsies revealed a great heterogeneity of COVID-19-associated organ injury and the remarkable absence of any specific viral lesions, even when RT-PCR identified the presence of the virus in many organs.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Remmelink</LastName><ForeName>Myriam</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Mendonça</LastName><ForeName>Ricardo</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>D'Haene</LastName><ForeName>Nicky</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Clercq</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verocq</LastName><ForeName>Camille</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lebrun</LastName><ForeName>Laetitia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lavis</LastName><ForeName>Philomène</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Racu</LastName><ForeName>Marie-Lucie</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trépant</LastName><ForeName>Anne-Laure</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre Universitaire inter Régional d'expertise en Anatomie Pathologique Hospitalière (CurePath, CHIREC, CHU Tivoli, ULB), Rue de Borfilet 12A, 6040, Jumet, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maris</LastName><ForeName>Calliope</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rorive</LastName><ForeName>Sandrine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre Universitaire inter Régional d'expertise en Anatomie Pathologique Hospitalière (CurePath, CHIREC, CHU Tivoli, ULB), Rue de Borfilet 12A, 6040, Jumet, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goffard</LastName><ForeName>Jean-Christophe</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Immunodeficiency Treatment Unit, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Witte</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peluso</LastName><ForeName>Lorenzo</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vincent</LastName><ForeName>Jean-Louis</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Decaestecker</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Laboratory of Image Synthesis and Analysis (LISA), Université Libre de Bruxelles (ULB), CPI 165/57, Avenue Franklin Roosevelt 50, 1050, Brussels, Belgium.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>DIAPath, Center for Microscopy and Molecular Imaging, Université Libre de Bruxelles (ULB), CPI 305/1, Rue Adrienne Bolland, 8, 6041, Gosselies, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taccone</LastName><ForeName>Fabio Silvio</ForeName><Initials>FS</Initials><AffiliationInfo><Affiliation>Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salmon</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><Identifier Source="ORCID">0000-0002-7732-2863</Identifier><AffiliationInfo><Affiliation>Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium. Isabelle.Salmon@erasme.ulb.ac.be.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre Universitaire inter Régional d'expertise en Anatomie Pathologique Hospitalière (CurePath, CHIREC, CHU Tivoli, ULB), Rue de Borfilet 12A, 6040, Jumet, Belgium. Isabelle.Salmon@erasme.ulb.ac.be.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>DIAPath, Center for Microscopy and Molecular Imaging, Université Libre de Bruxelles (ULB), CPI 305/1, Rue Adrienne Bolland, 8, 6041, Gosselies, Belgium. Isabelle.Salmon@erasme.ulb.ac.be.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>411132-957270</GrantID><Agency>Walloon Region of Belgium</Agency><Country>International</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Crit Care</MedlineTA><NlmUniqueID>9801902</NlmUniqueID><ISSNLinking>1364-8535</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001344" MajorTopicYN="N">Autopsy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003106" MajorTopicYN="N">Colon</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006321" MajorTopicYN="N">Heart</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007668" MajorTopicYN="N">Kidney</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013154" MajorTopicYN="N">Spleen</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Autopsy</Keyword><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">Immunohistochemistry</Keyword><Keyword MajorTopicYN="Y">RT-PCR</Keyword><Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32787909</ArticleId><ArticleId IdType="doi">10.1186/s13054-020-03218-5</ArticleId><ArticleId IdType="pii">10.1186/s13054-020-03218-5</ArticleId><ArticleId 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IdType="pubmed">19118274</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Belgique</li></country><region><li>Région de Bruxelles-Capitale</li></region><settlement><li>Bruxelles</li></settlement><orgName><li>Université libre de Bruxelles</li></orgName></list><tree><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Remmelink, Myriam" sort="Remmelink, Myriam" uniqKey="Remmelink M" first="Myriam" last="Remmelink">Myriam Remmelink</name></region><name sortKey="D Haene, Nicky" sort="D Haene, Nicky" uniqKey="D Haene N" first="Nicky" last="D'Haene">Nicky D'Haene</name><name sortKey="De Clercq, Sarah" sort="De Clercq, Sarah" uniqKey="De Clercq S" first="Sarah" last="De Clercq">Sarah De Clercq</name><name sortKey="De Mendonca, Ricardo" sort="De Mendonca, Ricardo" uniqKey="De Mendonca R" first="Ricardo" last="De Mendonça">Ricardo De Mendonça</name><name sortKey="De Witte, Olivier" sort="De Witte, Olivier" uniqKey="De Witte O" first="Olivier" last="De Witte">Olivier De Witte</name><name sortKey="Decaestecker, Christine" sort="Decaestecker, Christine" uniqKey="Decaestecker C" first="Christine" last="Decaestecker">Christine Decaestecker</name><name sortKey="Decaestecker, Christine" sort="Decaestecker, Christine" uniqKey="Decaestecker C" first="Christine" last="Decaestecker">Christine Decaestecker</name><name sortKey="Goffard, Jean Christophe" sort="Goffard, Jean Christophe" uniqKey="Goffard J" first="Jean-Christophe" last="Goffard">Jean-Christophe Goffard</name><name sortKey="Lavis, Philomene" sort="Lavis, Philomene" uniqKey="Lavis P" first="Philomène" last="Lavis">Philomène Lavis</name><name sortKey="Lebrun, Laetitia" sort="Lebrun, Laetitia" uniqKey="Lebrun L" first="Laetitia" last="Lebrun">Laetitia Lebrun</name><name sortKey="Maris, Calliope" sort="Maris, Calliope" uniqKey="Maris C" first="Calliope" last="Maris">Calliope Maris</name><name sortKey="Peluso, Lorenzo" sort="Peluso, 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Taccone</name><name sortKey="Trepant, Anne Laure" sort="Trepant, Anne Laure" uniqKey="Trepant A" first="Anne-Laure" last="Trépant">Anne-Laure Trépant</name><name sortKey="Trepant, Anne Laure" sort="Trepant, Anne Laure" uniqKey="Trepant A" first="Anne-Laure" last="Trépant">Anne-Laure Trépant</name><name sortKey="Verocq, Camille" sort="Verocq, Camille" uniqKey="Verocq C" first="Camille" last="Verocq">Camille Verocq</name><name sortKey="Vincent, Jean Louis" sort="Vincent, Jean Louis" uniqKey="Vincent J" first="Jean-Louis" last="Vincent">Jean-Louis Vincent</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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